
Catalog Number	AR0038PA
Chemical Name	2,2,4,4-Tetramethyltetrahydrofuran
CAS Number	3358-28-9
Molecular Formula	C8H16O
Molecular Weight	128.212
MDL Number	MFCD04972553
SMILES	CC1(C)OCC(C1)(C)C

2,2,4,4-Tetramethyltetrahydrofuran, also known as TMTHF, is a versatile solvent that finds wide application in chemical synthesis processes. This highly stable cyclic ether demonstrates excellent solvency power and low reactivity, making it ideal for use in a variety of reactions and transformations.In organic synthesis, 2,2,4,4-Tetramethyltetrahydrofuran serves as a valuable solvent for reactions such as Grignard and organolithium reactions, as well as metal-catalyzed cross-coupling reactions. Its ability to dissolve a wide range of organic and inorganic compounds, coupled with its low boiling point and high thermal stability, makes it a preferred choice for facilitating these reactions.Furthermore, the exceptional stability of TMTHF allows for its use in reactions involving sensitive reagents or intermediates, where other solvents may react undesirably. Its non-polar nature also makes it suitable for extractions and purifications in organic synthesis, aiding in the isolation of target compounds with high purity.Overall, 2,2,4,4-Tetramethyltetrahydrofuran plays a crucial role in modern chemical synthesis as a reliable solvent, enabling the efficient and effective execution of various reactions across different domains of organic chemistry.